New research published in the International Journal of Impotence Research suggests that the role of Peyronie’s disease (PD) in the development of erectile dysfunction (ED) remains unclear.
According to past studies, 22% to 54% of men with Peyronie’s disease also have ED, depending on definitions and criteria used by researchers. However, the reasons behind these rates have been difficult to clarify, especially when comorbid conditions like diabetes and heart disease are so common in men with ED.
For the current study, a team of American and Turkish researchers questioned whether the degree of Peyronie’s disease curvature and the direction of the curved penis affected a man’s erectile function, focusing on vasculogenic ED.
They examined data from 220 men with Peyronie’s disease. The participants’ mean age at diagnosis was 55.
Each man was given an intracorporal injection of prostaglandin E1 to induce an erection. This was followed by audiovisual sexual stimulation and penile duplex Doppler ultrasound (PDDU).
Based on PDDU results, almost 70% of the participants were considered to have vasculogenic ED, although only 36% of them self-reported the condition.
Sixty-eight percent had comorbidities associated with ED, including hypertension (about one-quarter), diabetes (8%), and coronary artery disease (8%).
The extent and direction of the curvature did not seem to affect the type of erectile dysfunction, however.
The authors concluded, “The role of PD in the development of ED remains unclear at the present time.”
They noted that other researchers have found higher rates of comorbid conditions in men with PD and ED.
“This suggests that PD-associated ED may be a better reflection of underlying comorbid status rather than the disease itself,” they explained.
The authors acknowledged several limitations. PDDU can be controversial in ED diagnosis, they said. They added that the International Index of Erectile Function (IIEF), commonly used to assess erectile function, was not used in this study. However, this tool has not been validated for patients with Peyronie’s disease.
Finally, they noted that the medically-induced erections used in this study might be different from erections men attained outside the clinical setting.
International Journal of Impotence Research
Serefoglu, E. C., et al.
“The direction and severity of penile curvature does not have an impact on concomitant vasculogenic erectile dysfunction in patients with Peyronie’s disease”
(Full-text. First published online: July 17, 2014)